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You may be more likely to have a broken bone while taking this medicine long term or more than once per day.

Patients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treated.

In adultssymptomatic response to therapy with NEXIUM does not preclude the presence of gastric malignancyConsider additional follow-up and diagnostic testing in adult patients who have a suboptimal response or an early symptomatic relapse after completing treatment with a PPIIn older patientsalso consider an endoscopy.

Pathological Hypersecretory Conditions Including Zollinger-Ellis On Syndrome.

Daily treatment with any acid-suppressing medications over a long period of timee.glonger than 3 yearsmay lead to malabsorption of cyanocobalaminvitamin B-12caused by hypoor achlorhydriaRare reports of cyanocobalamin deficiency occurring with acid-suppressing therapy have been reported in the literatureThis diagnosis should be considered if clinical symptoms consistent with cyanocobalamin deficiency are observed.

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